Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.
Identifieur interne : 000138 ( Main/Exploration ); précédent : 000137; suivant : 000139Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.
Auteurs : Evan A. Elko [États-Unis] ; Brian Cunniff [États-Unis] ; David J. Seward [États-Unis] ; Shi Biao Chia [États-Unis] ; Reem Aboushousha [États-Unis] ; Cheryl Van De Wetering [États-Unis] ; Jos Van Der Velden [États-Unis] ; Allison Manuel [États-Unis] ; Arti Shukla [États-Unis] ; Nicholas H. Heintz [États-Unis] ; Vikas Anathy [États-Unis] ; Albert Van Der Vliet [États-Unis] ; Yvonne M W. Janssen-Heininger [États-Unis]Source :
- Antioxidants & redox signaling [ 1557-7716 ] ; 2019.
Descripteurs français
- KwdFr :
- MESH :
- métabolisme : Maladies pulmonaires, Peroxirédoxines, Poumon.
- Animaux, Humains, Oxydoréduction.
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Peroxiredoxins.
- metabolism : Lung, Lung Diseases.
- Animals, Humans, Oxidation-Reduction.
Abstract
Significance: The lung is a unique organ, as it is constantly exposed to air, and thus it requires a robust antioxidant defense system to prevent the potential damage from exposure to an array of environmental insults, including oxidants. The peroxiredoxin (PRDX) family plays an important role in scavenging peroxides and is critical to the cellular antioxidant defense system. Recent Advances: Exciting discoveries have been made to highlight the key features of PRDXs that regulate the redox tone. PRDXs do not act in isolation as they require the thioredoxin/thioredoxin reductase/NADPH, sulfiredoxin (SRXN1) redox system, and in some cases glutaredoxin/glutathione, for their reduction. Furthermore, the chaperone function of PRDXs, controlled by the oxidation state, demonstrates the versatility in redox regulation and control of cellular biology exerted by this class of proteins. Critical Issues: Despite the long-known observations that redox perturbations accompany a number of pulmonary diseases, surprisingly little is known about the role of PRDXs in the etiology of these diseases. In this perspective, we review the studies that have been conducted thus far to address the roles of PRDXs in lung disease, or experimental models used to study these diseases. Intriguing findings, such as the secretion of PRDXs and the formation of autoantibodies, raise a number of questions about the pathways that regulate secretion, redox status, and immune response to PRDXs. Future Directions: Further understanding of the mechanisms by which individual PRDXs control lung inflammation, injury, repair, chronic remodeling, and cancer, and the importance of PRDX oxidation state, configuration, and client proteins that govern these processes is needed.
DOI: 10.1089/ars.2019.7752
PubMed: 30799628
PubMed Central: PMC6767868
Affiliations:
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Elko</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cunniff, Brian" sort="Cunniff, Brian" uniqKey="Cunniff B" first="Brian" last="Cunniff">Brian Cunniff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Seward, David J" sort="Seward, David J" uniqKey="Seward D" first="David J" last="Seward">David J. 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Elko</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Cunniff, Brian" sort="Cunniff, Brian" uniqKey="Cunniff B" first="Brian" last="Cunniff">Brian Cunniff</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Seward, David J" sort="Seward, David J" uniqKey="Seward D" first="David J" last="Seward">David J. Seward</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Chia, Shi Biao" sort="Chia, Shi Biao" uniqKey="Chia S" first="Shi Biao" last="Chia">Shi Biao Chia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Aboushousha, Reem" sort="Aboushousha, Reem" uniqKey="Aboushousha R" first="Reem" last="Aboushousha">Reem Aboushousha</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Van De Wetering, Cheryl" sort="Van De Wetering, Cheryl" uniqKey="Van De Wetering C" first="Cheryl" last="Van De Wetering">Cheryl Van De Wetering</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Van Der Velden, Jos" sort="Van Der Velden, Jos" uniqKey="Van Der Velden J" first="Jos" last="Van Der Velden">Jos Van Der Velden</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Manuel, Allison" sort="Manuel, Allison" uniqKey="Manuel A" first="Allison" last="Manuel">Allison Manuel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Shukla, Arti" sort="Shukla, Arti" uniqKey="Shukla A" first="Arti" last="Shukla">Arti Shukla</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Heintz, Nicholas H" sort="Heintz, Nicholas H" uniqKey="Heintz N" first="Nicholas H" last="Heintz">Nicholas H. Heintz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Anathy, Vikas" sort="Anathy, Vikas" uniqKey="Anathy V" first="Vikas" last="Anathy">Vikas Anathy</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Van Der Vliet, Albert" sort="Van Der Vliet, Albert" uniqKey="Van Der Vliet A" first="Albert" last="Van Der Vliet">Albert Van Der Vliet</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author><author><name sortKey="Janssen Heininger, Yvonne M W" sort="Janssen Heininger, Yvonne M W" uniqKey="Janssen Heininger Y" first="Yvonne M W" last="Janssen-Heininger">Yvonne M W. Janssen-Heininger</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</nlm:affiliation><country xml:lang="fr">États-Unis</country><placeName><region type="state">Vermont</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington</wicri:cityArea></affiliation></author></analytic><series><title level="j">Antioxidants & redox signaling</title><idno type="eISSN">1557-7716</idno><imprint><date when="2019" type="published">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals (MeSH)</term><term>Humans (MeSH)</term><term>Lung (metabolism)</term><term>Lung Diseases (metabolism)</term><term>Oxidation-Reduction (MeSH)</term><term>Peroxiredoxins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux (MeSH)</term><term>Humains (MeSH)</term><term>Maladies pulmonaires (métabolisme)</term><term>Oxydoréduction (MeSH)</term><term>Peroxirédoxines (métabolisme)</term><term>Poumon (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peroxiredoxins</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Lung</term><term>Lung Diseases</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Maladies pulmonaires</term><term>Peroxirédoxines</term><term>Poumon</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Oxidation-Reduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Oxydoréduction</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><b><i>Significance:</i></b> The lung is a unique organ, as it is constantly exposed to air, and thus it requires a robust antioxidant defense system to prevent the potential damage from exposure to an array of environmental insults, including oxidants. The peroxiredoxin (PRDX) family plays an important role in scavenging peroxides and is critical to the cellular antioxidant defense system. <b><i>Recent Advances:</i></b> Exciting discoveries have been made to highlight the key features of PRDXs that regulate the redox tone. PRDXs do not act in isolation as they require the thioredoxin/thioredoxin reductase/NADPH, sulfiredoxin (SRXN1) redox system, and in some cases glutaredoxin/glutathione, for their reduction. Furthermore, the chaperone function of PRDXs, controlled by the oxidation state, demonstrates the versatility in redox regulation and control of cellular biology exerted by this class of proteins. <b><i>Critical Issues:</i></b> Despite the long-known observations that redox perturbations accompany a number of pulmonary diseases, surprisingly little is known about the role of PRDXs in the etiology of these diseases. In this perspective, we review the studies that have been conducted thus far to address the roles of PRDXs in lung disease, or experimental models used to study these diseases. Intriguing findings, such as the secretion of PRDXs and the formation of autoantibodies, raise a number of questions about the pathways that regulate secretion, redox status, and immune response to PRDXs. <b><i>Future Directions:</i></b> Further understanding of the mechanisms by which individual PRDXs control lung inflammation, injury, repair, chronic remodeling, and cancer, and the importance of PRDX oxidation state, configuration, and client proteins that govern these processes is needed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">30799628</PMID><DateCompleted><Year>2020</Year><Month>09</Month><Day>10</Day></DateCompleted><DateRevised><Year>2020</Year><Month>11</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1557-7716</ISSN><JournalIssue CitedMedium="Internet"><Volume>31</Volume><Issue>14</Issue><PubDate><Year>2019</Year><Month>11</Month><Day>10</Day></PubDate></JournalIssue><Title>Antioxidants & redox signaling</Title><ISOAbbreviation>Antioxid Redox Signal</ISOAbbreviation></Journal><ArticleTitle>Peroxiredoxins and Beyond; Redox Systems Regulating Lung Physiology and Disease.</ArticleTitle><Pagination><MedlinePgn>1070-1091</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1089/ars.2019.7752</ELocationID><Abstract><AbstractText><b><i>Significance:</i></b> The lung is a unique organ, as it is constantly exposed to air, and thus it requires a robust antioxidant defense system to prevent the potential damage from exposure to an array of environmental insults, including oxidants. The peroxiredoxin (PRDX) family plays an important role in scavenging peroxides and is critical to the cellular antioxidant defense system. <b><i>Recent Advances:</i></b> Exciting discoveries have been made to highlight the key features of PRDXs that regulate the redox tone. PRDXs do not act in isolation as they require the thioredoxin/thioredoxin reductase/NADPH, sulfiredoxin (SRXN1) redox system, and in some cases glutaredoxin/glutathione, for their reduction. Furthermore, the chaperone function of PRDXs, controlled by the oxidation state, demonstrates the versatility in redox regulation and control of cellular biology exerted by this class of proteins. <b><i>Critical Issues:</i></b> Despite the long-known observations that redox perturbations accompany a number of pulmonary diseases, surprisingly little is known about the role of PRDXs in the etiology of these diseases. In this perspective, we review the studies that have been conducted thus far to address the roles of PRDXs in lung disease, or experimental models used to study these diseases. Intriguing findings, such as the secretion of PRDXs and the formation of autoantibodies, raise a number of questions about the pathways that regulate secretion, redox status, and immune response to PRDXs. <b><i>Future Directions:</i></b> Further understanding of the mechanisms by which individual PRDXs control lung inflammation, injury, repair, chronic remodeling, and cancer, and the importance of PRDX oxidation state, configuration, and client proteins that govern these processes is needed.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Elko</LastName><ForeName>Evan A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunniff</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seward</LastName><ForeName>David J</ForeName><Initials>DJ</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chia</LastName><ForeName>Shi Biao</ForeName><Initials>SB</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aboushousha</LastName><ForeName>Reem</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van de Wetering</LastName><ForeName>Cheryl</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Velden</LastName><ForeName>Jos</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manuel</LastName><ForeName>Allison</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shukla</LastName><ForeName>Arti</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Heintz</LastName><ForeName>Nicholas H</ForeName><Initials>NH</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anathy</LastName><ForeName>Vikas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, Vermont.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>van der Vliet</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department 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